Comparison with AEDs
Efficacy Comparisons - Response
Number needed to treat (range) to obtain one extra 50% responder over placebo for new AEDs
van
Rijckevorsel, Seizure 2001;10:235-236
Success rates (AED minus placebo responder rates)
for new AEDs and vagal nerve stimulation
Tolerability Comparisons
Odds ratios (95% confidence intervals) for withdrawal for any reason from add-on treatment with new AEDs
Adapted from:
1 Marson et al., Epilepsia 1997;38(8):859-880
2 Castillo et al., Cochrane Database Syst Rev 2000;(3):CD 002028
3 Chaisewikul et al., Cochrane Database Syst Rev 2001;(1):CD001901
4 Chadwick et al., Cochrane Database Syst Rev 2002;(2): CD 001416
1 Marson et al., Epilepsia 1997;38(8):859-880
2 Castillo et al., Cochrane Database Syst Rev 2000;(3):CD 002028
3 Chaisewikul et al., Cochrane Database Syst Rev 2001;(1):CD001901
4 Chadwick et al., Cochrane Database Syst Rev 2002;(2): CD 001416
Complaint rates for the most frequently occuring adverse events in add-on therapy - new AEDs
No trade-off between efficacy and tolerability for levetiracetam
Odds ratios for response vs odds ratios for withdrawal of new AEDs
Adapted from:
1 Marson et al., Epilepsia 1997;38(8):859-880
2 Castillo et al., Cochrane Database Syst Rev 2000;(3):CD
002028
3 Chaisewikul et al., Cochrane Database Syst Rev
2001;(1):CD001901
4 Chadwick et al., Cochrane Database Syst Rev 2002;(2):
CD 001416
Fritz NE, Elger CE, Helmstaedter C. Epilepsia. 2005;46(suppl):106-107
Cognitive side effects of the newer antiepileptic drugs: results from the Columbia Antiepileptic Drug Database.
Weintraub D, Buchsbaum R, Spencer HT, et al. Neurology. 2004;62(suppl):A311
Evidence for early efficacy of levetiracetam in refractory epilepsy patients: an open-label study.
Specchio LM, Boero G, Specchio N, et al. Epilepsia. 2003;44:115-116
Long-Term Retention Rates of Lamotrigine, Gabapentin, and Topiramate in Chronic Epilepsy
S. D. Lhatoo et al. Epilepsia 41 (12), 1592–1596, 2000
